Insights into reference point indentation involving human cortical bone: Sensitivity to tissue anisotropy and mechanical behavior

Estimation of local anisotropy of plexiform bone: Comparison between depth sensing micro-indentation and Reference Point Indentation.

The recently developed Reference Point Indentation (RPI) allows the measurements of bone properties at the tissue level in vivo. The goal of this study was to compare the local anisotropic behaviour of bovine plexiform bone measured with depth sensing micro-indentation tests and with RPI. Fifteen plexiform bone specimens were extracted from a bovine femur and polished down to 0.05µm alumina pas...

Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis.

Glucocorticoids, widely used in inflammatory disorders, rapidly increase bone fragility and, therefore, fracture risk. However, common bone densitometry measurements are not sensitive enough to detect these changes. Moreover, densitometry only partially recognizes treatment-induced fracture reductions in osteoporosis. Here, we tested whether the reference point indentation technique could detec...

Bone Tissue Quality Determination of Mice Through a Novel Reference Point Indentation Technique

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Investigation of Ultrastructural and Mechanical Properties of Rat Cortical Bone Using Micro-ct, Three- Point Bending Testing, and the Reference Point Indentation Technique By

Anisotropy Nanoindentation Properties of Human Cortical Bone

INTRODUCTION Cortical bone is an anisotropic material, and its mechanical properties are determined by its composition as well as its microstructure. On the microstructure level (a few microns), cortical bone is composed primarily of single osteons and interstitial lamellae. Nanoindentation has been shown to be an effective technique to probe mechanical properties of microstructures at the micr...